In vivo retinal imaging by optical coherence tomography. Swanson EA, Izatt JA, Hee MR, Huang D, Lin CP, Schuman JS, Puliafito CA, Fujimoto JG. Device for measuring the light wave of a reflected image. Micron-resolution ranging of cornea and anterior chamber by optical reflectometry. ![]() Huang D, Wang J, Lin CP, Puliafito CA, Fujimoto JG. Optical multimode time-domain reflectometry. Reproduction of optical reflection-intensity-distribution using multi-mode laser coherence. Measurement of optical-properties of biological tissues by low- coherence reflectometry. High-speed optical coherence domain reflectometry. Swanson EA, Huang D, Hee MR, Fujimoto JG, Lin CP, Puliafito CA. High-resolution reflectometry in biological tissues. ![]() 1988 13:1867–9.Ĭlivaz X, Marquis-Weible F, Salathe RP, Novak RP, Gilgen HH. Eye-length measurement by interferometry with partially coherent light. Optical coherence-domain reflectometry: a new optical evaluation technique. New measurement system for fault location in optical waveguide devices based on an interferometric technique. Femtosecond optical ranging in biological systems. 1981 20:2389–94.įujimoto JG, De Silvestri S, Ippen EP, Puliafito CA, Margolis R, Oseroff A. Picosecond light scattering measurements of cataract microstructure. Ultrahigh speed photography of picosecond light pulses and echoes. The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact. The development, commercialization, and impact of optical coherence tomography. Properties and demonstration of vascular pathology. Optical coherence tomography for optical biopsy. 1995 1:970–2.īrezinski ME, Tearney GJ, Bouma BE, Izatt JA, Hee MR, Swanson EA, Southern JF, Fujimoto JG. Optical biopsy and imaging using optical coherence tomography. 1991 254:1178–81.įujimoto JG, Brezinski ME, Tearney GJ, Boppart SA, Bouma B, Hee MR, Southern JF, Swanson EA. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA, Fujimoto JG. The history of commercial intravascular OCT development is also summarized. The process of clinical translation, beginning with ex vivo imaging and histology, preclinical animal studies and progressing to clinical studies in patients is discussed. Early OCT technology and catheter imaging devices as well as advances in imaging speed using swept source/Fourier domain detection are reviewed. This chapter reviews the early history of OCT development with an emphasis on basic concepts and the process of technology translation. OCT imaging has become a standard of care in ophthalmology and is an emerging imaging modality in cardiology, dermatology, gastroenterology and other specialties where it provides information that often cannot be obtained by any other means. OCT can perform an “optical biopsy”, imaging pathology in situ and in real time without the need for excisional biopsy. Optical coherence tomography angiography classification diabetic retinopathy eye condition eye disease quantitative analysis retinopathy sickle cell retinopathy.Optical coherence tomography (OCT) enables cross-sectional, volumetric, and functional imaging of internal microstructure and pathology in biological tissues. This review summarizes technical rationales and clinical applications of quantitative OCTA features. Quantitative analysis of OCTA is essential to standardize objective interpretations of clinical outcome. OCT angiography (OCTA) provides a noninvasive method to detect microvascular distortions correlated with eye conditions. In this review, technical rationales and clinical applications of these quantitative OCTA features are summarized, and future prospects for using these quantitative OCTA features for artificial intelligence classification of eye conditions are discussed. Moreover, differential artery–vein analysis has been recently demonstrated to improve OCTA performance for objective detection and classification of eye diseases. Quantitative features, including blood vessel tortuosity, blood vessel caliber, blood vessel density, vessel perimeter index, fovea avascular zone area, fovea avascular zone contour irregularity, vessel branching coefficient, vessel branching angle, branching width ratio, and choroidal vascular analysis have been established for objective OCTA assessment. Quantitative OCTA analysis of retinal and choroidal vasculatures is essential to standardize objective interpretations of clinical outcome. By providing unparalleled capability to differentiate individual plexus layers in the retina, OCTA has demonstrated its excellence in clinical management of diabetic retinopathy, glaucoma, sickle cell retinopathy, diabetic macular edema, and other eye diseases. ![]() As a new optical coherence tomography (OCT) modality, OCT angiography (OCTA) provides a noninvasive method to detect microvascular distortions correlated with eye conditions.
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